Workshop on Enhancing Cross-Platform Collaboration in Integrative Structural Biology

Integrative Structural Biology (ISB) is a rapidly advancing field that relies on the integration of diverse datasets, such as those from Cryo-electron microscopy, X-ray crystallography, NMR, Mass spectrometry and Modeling. By integrating different structural techniques we can solve the structure of challenging biological systems, which wouldn’t be possible using a single type of data. However, the current landscape is fragmented, with significant challenges in data interoperability, tool integration, and cross-disciplinary collaboration. The primary objective of this workshop is to foster cross-platform collaboration by bringing together key stakeholders from experimental and computational platforms.

The workshop aims: To facilitate the exchange of ideas and experiences, define the technical and scientific requirements for an Integrative Structural Biology Portal and engage with experts in multimodal data analysis.

This event is organized by SciLifeLab Lund and the Integrated Structural Biology Platform.

Register here: Workshop on Enhancing Cross-Platform Collaboration in Integrative Structural Biology

Preliminary Schedule 

Day 1 

• 12:00 – 13:00: Registration & Lunch
• 13:00 – 13:15 Welcome
• 13:15 – 14:00 Keynote Harald Schwalbe, Johann Wolfgang Goethe-University, Frankfurt. “The future of integrated structural biology – selected examples from the European Integrated Infrastructure: Instruct-ERIC”.
• 14:00 – 14:45 Selected talks I
• 14:45 – 15:15 Coffee Break
• 15:15 – 16:00 Keynote: Max Bonomi, Institut Pasteur, France. “Probabilistic approaches for integrative structural biology”
• 16:00 – 16:30 Ingemar André, Lund University, “How to optimally combine experimental data with molecular modeling to describe the structure of complex protein mixtures in solution”
• 16:30 – 17:15 Bridging the Gaps: Tackling Real-World Challenges in Integrative Structural Biology. (A panel discussion with infrastructure, data, and database experts on how to better support users in navigating experimental design, data integration, and reproducibility in integrative structural biology)
• 17:30 – 19:30 Workshop Mingle

Day 2 

• 09:00 – 09:15 Coffee
• 09:15 – 10:00 Björn Forsberg,  Linköping University, “Tools and perspectives for cryo-EM processing to answer biological questions”
• 10:00 – 10:30 Claudio Mirabello, Linköping University, “Integration of experimental restraints in protein structure predictions with AlphaFold”
• 10:30 – 11:00 Coffee Break
• 11:00 – 11:45 Karin Lindkvist, Lund University, "Aquaporins in health and disease"
• 11:45 – 12:15 Mikael Akke, Lund University, “Resolving Protein–Ligand Binding Pathways by NMR Relaxation”
• 12:15 – 13:15 Lunch
• 13:15 – 14:30 Panel Discussion: Multi-Modal AI: The Next Frontier in Structural Biology?
• 14:30 – 15:15 Final Plenary: Strategic Roadmap for Future Collaboration